LIST YOUR PRACTICE
Disclaimer
IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.
Uses
Tofacitinib is used to treat certain types of arthritis (such as psoriatic arthritis, rheumatoid arthritis, ankylosing spondylitis). It helps to decrease pain/tenderness/swelling in the joints. Tofacitinib is also used to treat a certain bowel disease (ulcerative colitis). It helps to reduce symptoms of ulcerative colitis such as diarrhea, rectal bleeding, and stomach pain.
How to Use
Read the Medication Guide provided by your pharmacist before you start taking tofacitinib and each time you get a refill.
If you have any questions, ask your doctor or pharmacist.
Take this medication by mouth with or without food as directed by your doctor, usually once daily.
Swallow the tablets whole.
Do not crush, split, or chew the tablets.
Doing so can release all of the drug at once, increasing the risk of side effects.
The dosage is based on your medical condition, response to treatment, lab tests, and other medications you may be taking.
Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
Do not increase your dose or use this drug more often or for longer than prescribed.
Your condition will not improve any faster, and your risk of serious side effects will increase.
Use this medication regularly to get the most benefit from it.
To help you remember, take it at the same time each day.
Tell your doctor if your condition does not get better or if it gets worse.
Side Effects
See also Warning section.
Headache or diarrhea may occur.
If either of these effects lasts or gets worse, tell your doctor or pharmacist promptly.
An empty tablet shell may appear in your stool.
This effect is harmless because your body has already absorbed the medication.
People using this medication may have serious side effects.
However, you have been prescribed this drug because your doctor has judged that the benefit to you is greater than the risk of side effects.
Careful monitoring by your doctor may decrease your risk.
Tell your doctor right away if you have any serious side effects, such as: unusual tiredness, fast heartbeat, signs of liver disease (such as nausea/vomiting that doesn't stop, loss of appetite, stomach/abdominal pain, yellowing eyes/skin, dark urine).
A very serious allergic reaction to this drug is rare.
However, get medical help right away if you notice any symptoms of a serious allergic reaction, such as: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects.
If you notice other effects not listed above, contact your doctor or pharmacist.
In the US - Call your doctor for medical advice about side effects.
You may report side effects to FDA at 1-800-FDA-1088 or at www.
fda.
gov/medwatch.
In Canada - Call your doctor for medical advice about side effects.
You may report side effects to Health Canada at 1-866-234-2345.
Precautions
See also Warning section.
Before taking tofacitinib, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies.
This product may contain inactive ingredients, which can cause allergic reactions or other problems.
Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: blood clots (such as in the lungs, legs), blood/bone marrow disorders (such as anemia, low lymphocyte/neutrophil count), cancer, heart problems (such as previous heart attack), kidney disease, liver disease (such as hepatitis B or C), lung disease, past/recent/current infections (such as tuberculosis, herpes zoster, HIV infection), current or past smoking, other stomach/intestinal disorders (such as ulcers, diverticulitis), stroke.
Tofacitinib can make you more likely to get infections or may make current infections worse.
Stay away from anyone who has an infection that may easily spread (such as chickenpox, COVID-19, measles, flu).
Talk to your doctor if you have been exposed to an infection or for more details.
Tell your health care professional that you are using tofacitinib before having any immunizations/vaccinations.
Avoid contact with people who have recently received live vaccines (such as flu vaccine inhaled through the nose).
Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
Older adults may be at greater risk for infections while using this drug.
During pregnancy, this medication should be used only when clearly needed.
Discuss the risks and benefits with your doctor.
This medication passes into breast milk.
Because of the possible risk to the infant, breastfeeding is not recommended while using this medication and for at least 36 hours after the last dose.
Consult your doctor before breastfeeding.
Drug Interactions
See also Warning section.
Drug interactions may change how your medications work or increase your risk for serious side effects.
This document does not contain all possible drug interactions.
Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist.
Do not start, stop, or change the dosage of any medicines without your doctor's approval.
Other medications can affect the removal of tofacitinib from your body, which may affect how tofacitinib works.
Examples include rifampin, among others.