LIST YOUR PRACTICE
Disclaimer
IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.
Uses
This medication is used by people with sickle cell anemia to reduce the number of painful crises caused by the disease and to reduce the need for blood transfusions. Some brands are also used to treat certain types of cancer (such as chronic myelogenous leukemia, squamous cell carcinomas).
How to Use
Read the Medication Guide if available from your pharmacist before you start taking hydroxyurea and each time you get a refill.
If you have any questions, ask your doctor or pharmacist.
Take this medication by mouth with or without food as directed by your doctor, usually once daily.
The dosage is based on your weight, medical condition, lab results, and response to treatment.
Your treatment may be stopped for a short time if your blood counts are too low.
Keep all medical and lab appointments.
Do not increase your dose or use this drug more often or for longer than prescribed.
Your condition will not improve any faster, and your risk of serious side effects will increase.
If you are using the capsules, swallow the them whole.
Do not crush, chew, or open the capsules.
If you are using the tablets, swallow your dose with a glass of water.
Only split a tablet if it has a score line and your doctor has instructed you to do so.
If you have trouble swallowing, you may dissolve the whole or split tablet in a small amount of water in a teaspoon and swallow it right away.
Wash hands before and after handling the medication or its container.
You and/or your caregiver should wear disposable gloves when handling this medication or its container.
If powder from the tablet or capsule spills, wipe it up right away with a wet paper towel and throw away in a closed container such as a plastic bag.
Clean the spill area right away with soap and water.
Make sure not to breathe the powder from the tablets/capsules.
Since this drug can be absorbed through the skin and lungs, women who are pregnant or who may become pregnant should not handle this medication or breathe the dust from the tablets/capsules.
Tell your doctor if your condition does not get better or if it gets worse.
Side Effects
See also Warning Section.
Nausea, vomiting, loss of appetite, mouth sores, diarrhea, or constipation may occur.
If any of these effects last or get worse, tell your doctor or pharmacist promptly.
People using this medication may have serious side effects.
However, you have been prescribed this drug because your doctor has judged that the benefit to you is greater than the risk of side effects.
Careful monitoring by your doctor may decrease your risk.
Tell your doctor right away if you have any serious side effects, including: skin problems (such as ulcers, darkened/blackened/reddened skin), mental/mood changes (such as confusion, hallucinations), seizures, shortness of breath, yellowing eyes/skin, dark/bloody urine, signs of kidney problems (such as change in the amount of urine).
Get medical help right away if you have any very serious side effects, including: chest pain.
A very serious allergic reaction to this drug is rare.
However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects.
If you notice other effects not listed above, contact your doctor or pharmacist.
In the US - Call your doctor for medical advice about side effects.
You may report side effects to FDA at 1-800-FDA-1088 or at www.
fda.
gov/medwatch.
In Canada - Call your doctor for medical advice about side effects.
You may report side effects to Health Canada at 1-866-234-2345.
Precautions
See also Warning section.
Before taking hydroxyurea, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies.
This product may contain inactive ingredients, which can cause allergic reactions or other problems.
Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: other blood/bone marrow problems (such as low red/white blood cells and platelets), kidney disease, liver disease, HIV infection, high uric acid level in the blood, radiation treatment.
Hydroxyurea can make you more likely to get infections or may make current infections worse.
Stay away from anyone who has an infection that may easily spread (such as chickenpox, COVID-19, measles, flu).
Talk to your doctor if you have been exposed to an infection or for more details.
Tell your health care professional that you are using hydroxyurea before having any immunizations/vaccinations.
Avoid contact with people who have recently received live vaccines (such as flu vaccine inhaled through the nose).
To lower the chance of getting cut, bruised, or injured, use caution with sharp objects like razors and nail cutters, and avoid activities such as contact sports.
Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
Older adults may be more sensitive to the side effects of this drug.
It is unknown if this medication affects sperm.
If you plan to father a child, discuss the risks and benefits of this medication with your doctor.
Tell your doctor if you are pregnant or plan to become pregnant.
You should not become pregnant while using hydroxyurea.
Hydroxyurea may harm an unborn baby.
Women using this medication should ask about reliable forms of birth control during treatment and for 6 months after the last dose.
Men using this medication should ask about reliable forms of birth control during treatment and for 1 year after the last dose.
If you or your partner becomes pregnant, talk to your doctor right away about the risks and benefits of this medication.
Hydroxyurea passes into breast milk and may have undesirable effects on a nursing infant.
Breastfeeding is not recommended while using this medication.
Consult your doctor before breastfeeding.
Drug Interactions
Drug interactions may change how your medications work or increase your risk for serious side effects.
This document does not contain all possible drug interactions.
Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist.
Do not start, stop, or change the dosage of any medicines without your doctor's approval.
Some products that may interact with this drug include: didanosine, stavudine.
This medication may interfere with certain lab tests (such as certain blood sugar tests), possibly causing false test results.
Make sure lab personnel and all your doctors know you use this drug.